Posttraumatic seizures - prevention or not

Propofol withdrawal seizures (or not)

Propofol is associated with abnormal motor events resembling seizures, the exact nature of these events remains to be elucidated. We describe here a case of seizure-like activity after propofol-induced conscious sedation accompanied by a prolactin rise, together suggesting that the event was ictal.

Treatment and Prevention of Posttraumatic Stress Disorder

What treatments are effective for chronic posttraumatic stress disorder (PTSD) and the prevention of PTSD following trauma? The current review illustrates the basic efficacy of several psychosocial treatments for PTSD (ie, exposure, stress inoculation training, eye movement desensitization and reprocessing, cognitive therapy); discusses comparative studies of these treatments; examines two prev...

Bisphosphonates for osteoarthritis prevention: "Holy Grail" or not?

The search for effective disease modifying osteoarthritis (OA) agents has been a long and winding road with much unrealised promise. While a debate persists about whether OA is predominately a disease of bone, cartilage, or both, there has been interest in the possible OA disease modifying effects of bone antiresorptive agents including oestrogens, selective oestrogen receptor modulators, calci...

Prevention of epileptic seizures by taurine.

Parenteral injection of kainic acid (KA), a glutamate receptor agonist, causes severe and stereotyped behavioral convulsions in mice and is used as a rodent model for human temporal lobe epilepsy. The goal of this study is to examine the potential anti-convulsive effects of the neuro-active amino acid taurine, in the mouse model of KA-induced limbic seizures. We found that taurine (43 mg/Kg, s....

Prevention of Seizures Following Traumatic Brain Injury